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Article

Hotspot mutant p53-R273H inhibits KLF6 expression to promote cell migration and tumor metastasis.

Cell death & disease - 30 Jul 2020

Sun Shengnan, Chen Hu, Sun Lijuan, Wang Miao, Wu Xianqiang, Xiao Zhi-Xiong Jim

Abstract excerpt

Hotspot p53 mutant proteins often gain novel functions in promoting tumor metastases. However, the molecular mechanisms by which mutant p53 exerts gain-of-function in cancer are not totally understood. In this study, we demonstrate that hotspot mutant p53, p53-R273H, promotes cell scattering growth and migration via inhibiting the expression of Krupple-like factor 6 (KLF6), a Zinc finger transcription factor and...

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Identifiers

PMID: 32733026
DOI: 10.1038/s41419-020-02814-1
PMCID: PMC7393383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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