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Article

Mesothelioma patient derived tumor xenografts with defined BAP1 mutations that mimic the molecular characteristics of human malignant mesothelioma.

BMC cancer - 8 May 2015

Kalra Neetu, Zhang Jingli, Thomas Anish, Xi Liqiang, Cheung Mitchell, Talarchek Jacqueline, Burkett Sandra, Tsokos Maria G, Chen Yuanbin, Raffeld Mark, Miettinen Markku, Pastan Ira, Testa Joseph R, Hassan Raffit

Abstract excerpt

BACKGROUND: The development and evaluation of new therapeutic approaches for malignant mesothelioma has been sparse due, in part, to lack of suitable tumor models. METHODS: We established primary mesothelioma cultures from pleural and ascitic fluids of five patients with advanced mesothelioma. Electron microscopy and immunohistochemistry (IHC) confirmed their mesothelial origin. Patient derived xenografts were...

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Source

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Identifiers

PMID: 25952750
DOI: 10.1186/s12885-015-1362-2
PMCID: PMC4431029

Genes

BAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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