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Article

Expression of Oncogenic Alleles Induces Multiple Blocks to Human Cytomegalovirus Infection.

Journal of virology - 1 May 2016

Xu Shihao, Schafer Xenia, Munger Joshua

Abstract excerpt

UNLABELLED: In contrast to many viruses, human cytomegalovirus (HCMV) is unable to productively infect most cancer-derived cell lines. The mechanisms of this restriction are unclear. To explore this issue, we tested whether defined oncogenic alleles, including the simian virus 40 (SV40) T antigen (TAg) and oncogenic H-Ras, inhibit HCMV infection. We found that expression of SV40 TAg blocks HCMV infection in human...

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Share to Antigens, Viral, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

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Share to Receptor, Platelet-Derived Growth Factor alpha

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Source

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Identifiers

PMID: 26889030
DOI: 10.1128/JVI.00179-16
PMCID: PMC4836323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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