Functional polymorphism of the renalase gene is associated with cardiac hypertrophy in female patients with aortic stenosis.

doi:10.1371/journal.pone.0186729

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Functional polymorphism of the renalase gene is associated with cardiac hypertrophy in female patients with aortic stenosis.

PloS one - 1 Jan 2017

Orlowska-Baranowska Ewa, Gadomska Vel Betka Lucja, Gora Jaroslaw, Baranowski Rafal, Pedzich-Placha Ewa, Zakrzewski Dariusz, Dlugosz Angelika, Kossowska Helena, Zebrowska Agnieszka, Zakoscielna Ewelina, Janiszewska Anna, Hryniewiecki Tomasz, Gaciong Zbigniew, Placha Grzegorz

Abstract excerpt

Renalase decreases circulating catecholamines concentration and is important in maintaining primary cellular metabolism. Renalase acts through the plasma membrane calcium ATPase 4b in the heart, which affects pressure overload but not exercise induced heart hypertrophy. The aim of this study was to test the association between a functional polymorphism Glu37Asp (rs2296545) of the renalase gene and left...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aortic Valve Stenosis

Share to Binding Sites

Share to Cardiomegaly

Share to Cohort Studies

Share to Echocardiography

Share to Monoamine Oxidase

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 29065134
DOI: 10.1371/journal.pone.0186729
PMCID: PMC5655536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional polymorphism of the renalase gene is associated with cardiac hypertrophy in female patients with aortic stenosis.PMID 29065134Read ↗

A functional polymorphism in renalase (Glu37Asp) is associated with cardiac hypertrophy, dysfunction, and ischemia: data from the heart and soul study.Semantic proximity Read ↗

Renalase gene polymorphism in patients with hypertension and concomitant coronary heart disease.Semantic proximity Read ↗

Uromodulin associates with cardiorenal function in patients with hypertension and cardiovascular disease.Semantic proximity Read ↗

Aldosterone synthase -344C/T and angiotensin-converting enzyme I/D polymorphisms in Turkish hypertensive patients with normal coronary arteries.Semantic proximity Read ↗

A Single Nucleotide Polymorphism near the CYP17A1 Gene Is Associated with Left Ventricular Mass in Hypertensive Patients under Pharmacotherapy.Semantic proximity Read ↗

Genetic polymorphisms of the natriuretic peptide system in the pathogenesis of cardiovascular disease: what lies on the horizon?Semantic proximity Read ↗

Pilot candidate gene analysis of patients ≥ 60 years old with aortic stenosis involving a tricuspid aortic valve.Semantic proximity Read ↗

Renalase gene polymorphism is associated with increased blood pressure in preeclampsia.Semantic proximity Read ↗

Renalase rs2296545 variant improve hypertension susceptibility by modifying binding affinity to catecholamines in obstructive sleep apnea.Semantic proximity Read ↗

Parathyroid hormone gene variant and calcific aortic stenosis.Semantic proximity Read ↗

Post-Transcriptional Regulation of Renalase Gene by miR-29 and miR-146 MicroRNAs: Implications for Cardiometabolic Disorders.Semantic proximity Read ↗

Corin I555(P568) allele is associated with enhanced cardiac hypertrophic response to increased systemic afterload.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.