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On the origin of sperm epigenetic heterogeneity

16 Feb 2016

Abstract excerpt

The influence of epigenetic modifications on reproduction and on the function of male germ cells has been thoroughly demonstrated. In particular, aberrant DNA methylation levels in sperm have been associated with abnormal sperm parameters, lower fertilization rates and impaired embryo development. Recent reports have indicated that human sperm might be epigenetically heterogeneous and that abnormal DNA...

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PMID: 26884419
DOI: 10.1530/rep-15-0436

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