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Article

Molecular model for force production and transmission during vertebrate gastrulation.

Development (Cambridge, England) - 15 Feb 2016

Pfister Katherine, Shook David R, Chang Chenbei, Keller Ray, Skoglund Paul

Abstract excerpt

Vertebrate embryos undergo dramatic shape changes at gastrulation that require locally produced and anisotropically applied forces, yet how these forces are produced and transmitted across tissues remains unclear. We show that depletion of myosin regulatory light chain (RLC) levels in the embryo blocks force generation at gastrulation through two distinct mechanisms: destabilizing the myosin II (MII) hexameric...

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Identifiers

PMID: 26884399
DOI: 10.1242/dev.128090
PMCID: PMC4760319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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