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Article

Nonmuscle myosin II exerts tension but does not translocate actin in vertebrate cytokinesis.

Proceedings of the National Academy of Sciences of the United States of America - 20 Mar 2012

Ma Xuefei, Kovács Mihály, Conti Mary Anne, Wang Aibing, Zhang Yingfan, Sellers James R, Adelstein Robert S

Abstract excerpt

During vertebrate cytokinesis it is thought that contractile ring constriction is driven by nonmuscle myosin II (NM II) translocation of antiparallel actin filaments. Here we report in situ, in vitro, and in vivo observations that challenge this hypothesis. Graded knockdown of NM II in cultured COS-7 cells reveals that the amount of NM II limits ring constriction. Restoration of the constriction rate with...

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Identifiers

PMID: 22393000
DOI: 10.1073/pnas.1116268109
PMCID: PMC3311360

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