Article
Multiplex Droplet Digital PCR Quantification of Recurrent Somatic Mutations in Diffuse Large B-Cell and Follicular Lymphoma.
Clinical chemistry - 1 Sept 2016
Alcaide Miguel, Yu Stephen, Bushell Kevin, Fornika Daniel, Nielsen Julie S, Nelson Brad H, Mann Koren K, Assouline Sarit, Johnson Nathalie A, Morin Ryan D
Abstract excerpt
BACKGROUND: A plethora of options to detect mutations in tumor-derived DNA currently exist but each suffers limitations in analytical sensitivity, cost, or scalability. Droplet digital PCR (ddPCR) is an appealing technology for detecting the presence of specific mutations based on a priori knowledge and can be applied to tumor biopsies, including formalin-fixed paraffin embedded (FFPE) tissues. More recently,...
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