Article
Impacts on Sirtuin Function and Bioavailability of the Dietary Bioactive Compound Dihydrocoumarin.
PloS one - 1 Jan 2016
Jacobi Jennifer L, Yang Bo, Li Xu, Menze Anna K, Laurentz Sara M, Janle Elsa M, Ferruzzi Mario G, McCabe George P, Chapple Clint, Kirchmaier Ann L
Abstract excerpt
The plant secondary metabolite and common food additive dihydrocoumarin (DHC) is an inhibitor of the Sirtuin family of NAD+-dependent deacetylases. Sirtuins are key regulators of epigenetic processes that maintain silent chromatin in yeast and have been linked to gene expression, metabolism, apoptosis, tumorogenesis and age-related processes in multiple organisms, including humans. Here we report that exposure to...
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