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Article

Alkylresorcinols activate SIRT1 and delay ageing in Drosophila melanogaster.

Scientific reports - 2 Mar 2017

Kayashima Yasunari, Katayanagi Yuki, Tanaka Keiko, Fukutomi Ryuta, Hiramoto Shigeru, Imai Shinjiro

Abstract excerpt

Sirtuins are enzymes that catalyze NAD+ dependent protein deacetylation. The natural polyphenolic compound resveratrol received renewed interest when recent findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction. However, resveratrol directly interacts with fluorophore-containing peptide substrates. It was demonstrated that the SIRT1 activation of...

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Identifiers

PMID: 28252007
DOI: 10.1038/srep43679
PMCID: PMC5333101

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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