Race-Specific Influence of CYP4F2 on Dose and Risk of Hemorrhage Among Warfarin Users.

doi:10.1002/phar.1717

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Article

Race-Specific Influence of CYP4F2 on Dose and Risk of Hemorrhage Among Warfarin Users.

Pharmacotherapy - 1 Mar 2016

Shendre Aditi, Brown Todd M, Liu Nianjun, Hill Charles E, Beasley T Mark, Nickerson Deborah A, Limdi Nita A

Abstract excerpt

OBJECTIVE: The p.V433M in cytochrome P450 4F2 (rs2108622, CYP4F2*3) is associated with a higher warfarin dose and lower risk of hemorrhage among European Americans. We evaluate the influence of CYP4F2*3 on warfarin dose, time to target international normalized ratio (INR), and stable dose, proportion of time spent in target range (PTTR), as well as the risk of overanticoagulation and hemorrhage among European and...

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PMID: 26877068
DOI: 10.1002/phar.1717
PMCID: PMC4803610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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