Article
HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing.
PloS one - 1 Jan 2015
Rhee Soo-Yon, Jordan Michael R, Raizes Elliot, Chua Arlene, Parkin Neil, Kantor Rami, Van Zyl Gert U, Mukui Irene, Hosseinipour Mina C, Frenkel Lisa M, Ndembi Nicaise, Hamers Raph L, Rinke de Wit Tobias F, Wallis Carole L, Gupta Ravindra K, Fokam Joseph, Zeh Clement, Schapiro Jonathan M, Carmona Sergio, Katzenstein David, Tang Michele, Aghokeng Avelin F, De Oliveira Tulio, Wensing Annemarie M J, Gallant Joel E, Wainberg Mark A, Richman Douglas D, Fitzgibbon Joseph E, Schito Marco, Bertagnolio Silvia, Yang Chunfu, Shafer Robert W
Abstract excerpt
The increasing prevalence of acquired and transmitted HIV-1 drug resistance is an obstacle to successful antiretroviral therapy (ART) in the low- and middle-income countries (LMICs) hardest hit by the HIV-1 pandemic. Genotypic drug resistance testing could facilitate the choice of initial ART in areas with rising transmitted drug resistance (TDR) and enable care-providers to determine which individuals with...
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