Article
Targeted sequencing using a 47 gene multiple myeloma mutation panel (M(3) P) in -17p high risk disease.
British journal of haematology - 1 Feb 2015
Kortüm Klaus M, Langer Christian, Monge Jorge, Bruins Laura, Egan Jan B, Zhu Yuan X, Shi Chang Xin, Jedlowski Patrick, Schmidt Jessica, Ojha Juhi, Bullinger Lars, Liebisch Peter, Kull Miriam, Champion Mia D, Van Wier Scott, Ahmann Gregory, Rasche Leo, Knop Stefan, Fonseca Rafael, Einsele Hermann, Stewart A Keith, Braggio Esteban
Abstract excerpt
We constructed a multiple myeloma (MM)-specific gene panel for targeted sequencing and investigated 72 untreated high-risk (del17p) MM patients. Mutations were identified in 78% of the patients. While the majority of studied genes were mutated at similar frequency to published literature, the prevalence of TP53 mutation was increased (28%) and no mutations were found in FAM46C. This study provides a comprehensive...
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