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Article

Subtle alterations in breathing and heart rate control in the 5-HT1A receptor knockout mouse in early postnatal development.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Nov 2012

Barrett Karlene T, Kinney Hannah C, Li Aihua, Daubenspeck J Andrew, Leiter James C, Nattie Eugene E

Abstract excerpt

We hypothesized that absence of the 5-HT(1A) receptor would negatively affect the development of cardiorespiratory control. In conscious wild type (WT) and 5-HT(1A) receptor knockout (KO) mice, we measured resting ventilation (Ve), oxygen consumption (Vo(2)), heart rate (HR), breathing and HR variability, and the hypercapnic ventilatory response (HCVR) at postnatal day 5 (P5), day 15 (P15), and day 25 (P25). In...

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Identifiers

PMID: 22936722
DOI: 10.1152/japplphysiol.00939.2012
PMCID: PMC3524655

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