Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inactivation of the cytosolic and mitochondrial serine hydroxymethyl transferase genes in Leishmania major.

Molecular and biochemical parasitology - 1 Dec 2015

Roy Gaétan, Ouellette Marc

Abstract excerpt

Leishmania has two serine hydroxylmethyl transferase (SHMT) genes, one coding for a cytosolic and the other for a mitochondrial enzyme. Trypanosoma cruzi has only the gene coding for the cytosolic enzyme and Trypanosoma brucei has no SHMT. We tested whether these genes were dispensable for growth in Leishmania major. By gene inactivation we succeeded in generating three cells lines one without the cytosolic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Culture Media
Share to Cytosol
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glycine Hydroxymethyltransferase

Share to Leishmania major

Share to Mitochondria

Share to Mutation

Share to Serine

Source

Identifiers

PMID: 26868981
DOI: 10.1016/j.molbiopara.2016.02.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inactivation of the cytosolic and mitochondrial serine hydroxymethyl transferase genes in Leishmania major.PMID 26868981Read ↗

Sterol methyltransferase is required for optimal mitochondrial function and virulence in Leishmania majorSemantic proximity Read ↗

Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.Semantic proximity Read ↗

Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.Semantic proximity Read ↗

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum.Semantic proximity Read ↗

Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.Semantic proximity Read ↗

Ovothiol is a redundant part of a complex thiol network in promastigote <i>Leishmania mexicana</i>Semantic proximity Read ↗

Characterization of anti-silencing factor 1 in Leishmania major.Semantic proximity Read ↗

Leishmania donovani methionine adenosyltransferase. Role of cysteine residues in the recombinant enzyme.Semantic proximity Read ↗

Molecular Cloning, Characterization, and Regulation of the Human Mitochondrial Serine Hydroxymethyltransferase GeneSemantic proximity Read ↗

The presequence of Arabidopsis serine hydroxymethyltransferase SHM2 selectively prevents import into mesophyll mitochondria.Semantic proximity Read ↗

Functional analysis of an AMP forming acetyl CoA synthetase from Leishmania donovani by gene overexpression and targeted gene disruption approaches.Semantic proximity Read ↗

The role of the mitochondrial glycine cleavage complex in the metabolism and virulence of the protozoan parasite Leishmania major.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.