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Article

Paternal Allele Influences High Fat Diet-Induced Obesity

8 Jan 2014

Abstract excerpt

C57BL/6J (B6) mice are susceptible to high-fat diet (HFD)-induced obesity and have been used in metabolism research for many decades. However, the genetic component of HFD-induced obesity has not yet been elucidated. This study reports evidence for a paternal transmission of HFD-induced obesity and a correlated expression of Igf2 and Peg3 (paternal expressed gene 3) imprinted genes. We found that PWK mice are...

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PMID: 24416415
DOI: 10.1371/journal.pone.0085477

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