Article
A Simple Test of Class-Level Genetic Association Can Reveal Novel Cardiometabolic Trait Loci.
PloS one - 1 Jan 2016
Qian Jing, Nunez Sara, Reed Eric, Reilly Muredach P, Foulkes Andrea S
Abstract excerpt
BACKGROUND: Characterizing the genetic determinants of complex diseases can be further augmented by incorporating knowledge of underlying structure or classifications of the genome, such as newly developed mappings of protein-coding genes, epigenetic marks, enhancer elements and non-coding RNAs. METHODS: We apply a simple class-level testing framework, termed Genetic Class Association Testing (GenCAT), to...
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