Article
Truncating Erythropoietin Receptor Rearrangements in Acute Lymphoblastic Leukemia.
Cancer cell - 8 Feb 2016
Iacobucci Ilaria, Li Yongjin, Roberts Kathryn G, Dobson Stephanie M, Kim Jaeseung C, Payne-Turner Debbie, Harvey Richard C, Valentine Marcus, McCastlain Kelly, Easton John, Yergeau Donald, Janke Laura J, Shao Ying, Chen I-Ming L, Rusch Michael, Zandi Sasan, Kornblau Steven M, Konopleva Marina, Jabbour Elias, Paietta Elisabeth M, Rowe Jacob M, Pui Ching-Hon, Gastier-Foster Julie, Gu Zhaohui, Reshmi Shalini, Loh Mignon L, Racevskis Janis, Tallman Martin S, Wiernik Peter H, Litzow Mark R, Willman Cheryl L, McPherson John D, Downing James R, Zhang Jinghui, Dick John E, Hunger Stephen P, Mullighan Charles G
Abstract excerpt
Chromosomal rearrangements are a hallmark of acute lymphoblastic leukemia (ALL) and are important ALL initiating events. We describe four different rearrangements of the erythropoietin receptor gene EPOR in Philadelphia chromosome-like (Ph-like) ALL. All of these rearrangements result in truncation of the cytoplasmic tail of EPOR at residues similar to those mutated in primary familial congenital polycythemia,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.