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Article

Hemopoietic growth factor receptor abnormalities in leukemia.

Leukemia research - 1 Dec 1998

Alexander W S, Nicola N A

Abstract excerpt

Growth factor and cytokine control of hemopoiesis, the process of blood cell development, is mediated by specific interactions with cell-surface receptors. Hemopoietic growth factor receptors belong to two major families, the transmembrane protein tyrosine kinases and the hemopoietin receptors. Ligand binding stimulates receptor aggregation and activation resulting in transduction of signals that induce diverse...

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PMID: 9922074
DOI: 10.1016/s0145-2126(98)00110-6

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