Article
Coalescent Inference Using Serially Sampled, High-Throughput Sequencing Data from Intrahost HIV Infection.
Genetics - 1 Apr 2016
Dialdestoro Kevin, Sibbesen Jonas Andreas, Maretty Lasse, Raghwani Jayna, Gall Astrid, Kellam Paul, Pybus Oliver G, Hein Jotun, Jenkins Paul A
Abstract excerpt
Human immunodeficiency virus (HIV) is a rapidly evolving pathogen that causes chronic infections, so genetic diversity within a single infection can be very high. High-throughput "deep" sequencing can now measure this diversity in unprecedented detail, particularly since it can be performed at different time points during an infection, and this offers a potentially powerful way to infer the evolutionary dynamics...
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