Article
Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems.
Clinical pharmacology and therapeutics - 1 Oct 2014
Rasmussen-Torvik L J, Stallings S C, Gordon A S, Almoguera B, Basford M A, Bielinski S J, Brautbar A, Brilliant M H, Carrell D S, Connolly J J, Crosslin D R, Doheny K F, Gallego C J, Gottesman O, Kim D S, Leppig K A, Li R, Lin S, Manzi S, Mejia A R, Pacheco J A, Pan V, Pathak J, Perry C L, Peterson J F, Prows C A, Ralston J, Rasmussen L V, Ritchie M D, Sadhasivam S, Scott S A, Smith M, Vega A, Vinks A A, Volpi S, Wolf W A, Bottinger E, Chisholm R L, Chute C G, Haines J L, Harley J B, Keating B, Holm I A, Kullo I J, Jarvik G P, Larson E B, Manolio T, McCarty C A, Nickerson D A, Scherer S E, Williams M S, Roden D M, Denny J C
Abstract excerpt
We describe here the design and initial implementation of the eMERGE-PGx project. eMERGE-PGx, a partnership of the Electronic Medical Records and Genomics Network and the Pharmacogenomics Research Network, has three objectives: (i) to deploy PGRNseq, a next-generation sequencing platform assessing sequence variation in 84 proposed pharmacogenes, in nearly 9,000 patients likely to be prescribed drugs of interest...
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