Article
Escape Mutations in NS4B Render Dengue Virus Insensitive to the Antiviral Activity of the Paracetamol Metabolite AM404.
Antimicrobial agents and chemotherapy - 1 Apr 2016
van Cleef Koen W R, Overheul Gijs J, Thomassen Michael C, Marjakangas Jenni M, van Rij Ronald P
Abstract excerpt
Despite the enormous disease burden associated with dengue virus infections, a licensed antiviral drug is lacking. Here, we show that the paracetamol (acetaminophen) metabolite AM404 inhibits dengue virus replication. Moreover, we find that mutations in NS4B that were previously found to confer resistance to the antiviral compounds NITD-618 and SDM25N also render dengue virus insensitive to AM404. Our work...
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