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Article

Molecular Features and Functional Implications of Germline Variants in Triple-Negative Breast Cancer.

Journal of the National Cancer Institute - 1 Jul 2021

Ma Ding, Chen Si-Yu, Ren Jin-Xiao, Pei Yu-Chen, Jiang Cong-Wei, Zhao Shen, Xiao Yi, Xu Xiao-En, Liu Guang-Yu, Hu Xin, Liang Xiao-Zhen, Yu Ke-Da, Li Da-Qiang, Jiang Yi-Zhou, Shao Zhi-Ming

Abstract excerpt

BACKGROUND: The germline variant spectrum of triple-negative breast cancer (TNBC) is different from that of other subtypes and has demonstrated ethnic differences. However, the germline variants of TNBC among Chinese patients and its clinical significance remain unclear. METHODS: Using our multi-omics TNBC cohort (n = 325), we determined the spectrum of germline variants in TNBC and aimed to illustrate their...

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PMID: 33151324
DOI: 10.1093/jnci/djaa175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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