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Article

Genetic susceptibility to triple-negative breast cancer.

Cancer research - 1 Apr 2013

Stevens Kristen N, Vachon Celine M, Couch Fergus J

Abstract excerpt

Triple-negative breast cancers (TNBC), defined by the absence of estrogen receptor, progesterone receptor, and HER-2 expression, account for 12% to 24% of all breast cancers. TNBC is associated with early recurrence of disease and poor outcome. Germline mutations in the BRCA1 and BRCA2 breast cancer susceptibility genes have been associated with up to 15% of TNBC, and TNBC accounts for 70% of breast tumors...

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Source

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Identifiers

PMID: 23536562
DOI: 10.1158/0008-5472.CAN-12-1699
PMCID: PMC3654815

Genes

BRCA1
BRCA2
MDM4
ESR1
FTO
TERT
TOX3

Provenance

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