Article
Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Feb 2015
Couch Fergus J, Hart Steven N, Sharma Priyanka, Toland Amanda Ewart, Wang Xianshu, Miron Penelope, Olson Janet E, Godwin Andrew K, Pankratz V Shane, Olswold Curtis, Slettedahl Seth, Hallberg Emily, Guidugli Lucia, Davila Jaime I, Beckmann Matthias W, Janni Wolfgang, Rack Brigitte, Ekici Arif B, Slamon Dennis J, Konstantopoulou Irene, Fostira Florentia, Vratimos Athanassios, Fountzilas George, Pelttari Liisa M, Tapper William J, Durcan Lorraine, Cross Simon S, Pilarski Robert, Shapiro Charles L, Klemp Jennifer, Yao Song, Garber Judy, Cox Angela, Brauch Hiltrud, Ambrosone Christine, Nevanlinna Heli, Yannoukakos Drakoulis, Slager Susan L, Vachon Celine M, Eccles Diana M, Fasching Peter A
Abstract excerpt
PURPOSE: Recent advances in DNA sequencing have led to the development of breast cancer susceptibility gene panels for germline genetic testing of patients. We assessed the frequency of mutations in 17 predisposition genes, including BRCA1 and BRCA2, in a large cohort of patients with triple-negative breast cancer (TNBC) unselected for family history of breast or ovarian cancer to determine the utility of...
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