Germline mutations in DNA repair genes may predict neoadjuvant therapy response in triple negative breast patients.

doi:10.1002/gcc.22389

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Article

Germline mutations in DNA repair genes may predict neoadjuvant therapy response in triple negative breast patients.

Genes, chromosomes & cancer - 1 Dec 2016

Spugnesi Laura, Gabriele Michele, Scarpitta Rosa, Tancredi Mariella, Maresca Luisa, Gambino Gaetana, Collavoli Anita, Aretini Paolo, Bertolini Ilaria, Salvadori Barbara, Landucci Elisabetta, Fontana Andrea, Rossetti Elena, Roncella Manuela, Naccarato Giuseppe Antonio, Caligo Maria Adelaide

Abstract excerpt

Triple negative breast cancers (TNBCs) represent about 15-20% of all breast cancer cases and are characterized by a complex molecular heterogeneity. Some TNBCs exhibit clinical and pathological properties similar to BRCA-mutated tumors, without actually bearing a mutation in BRCA genes. This "BRCAness" phenotype may be explained by germline mutations in other genes involved in DNA repair. Although respond to...

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Identifiers

PMID: 27328445
DOI: 10.1002/gcc.22389

Genes

BRCA1
PALB2

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