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Fine‐Tuning Covalent Inhibition of Bacterial Quorum Sensing

3 Feb 2016

Abstract excerpt

Emerging antibiotic resistance among human pathogens has galvanized efforts to find alternative routes to combat bacterial virulence. One new approach entails interfering with the ability of bacteria to coordinate population-wide gene expression, or quorum sensing (QS), thus inhibiting the production of virulence factors and biofilm formation. We have recently developed such a strategy by targeting LasR, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26840534
DOI: 10.1002/cbic.201500676

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