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Article

Inhibitors of Pathogen Intercellular Signals as Selective Anti-Infective Compounds

10 Sept 2007

Abstract excerpt

Long-term antibiotic use generates pan-resistant super pathogens. Anti-infective compounds that selectively disrupt virulence pathways without affecting cell viability may be used to efficiently combat infections caused by these pathogens. A candidate target pathway is quorum sensing (QS), which many bacterial pathogens use to coordinately regulate virulence determinants. The Pseudomonas aeruginosa MvfR-dependent...

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Share to Antibiotic Resistance in Bacteria
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17941706
DOI: 10.1371/journal.ppat.0030126

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