Article

Iron exacerbates congenital cholestatic liver injury via bile acid-induced ferroptosis

2025-05-23

Abstract excerpt

<title>Abstract</title> <p>Pediatric cholestatic liver diseases are rare but serious conditions that frequently progress to liver fibrosis and cirrhosis and often require transplantation. Despite their clinical importance, the mechanisms driving disease progression remain poorly understood. Here, we report that hepatic iron accumulation is a pathological feature associated with congenital cholestatic liver diseas...

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Literature Corpus work: b8ed0c49-79f1-5ae0-aa68-6cba4e97aae6
DOI: 10.21203/rs.3.rs-6671814/v1

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