Article

Zebrafish models for human ALA-dehydratase-deficient porphyria (ADP) and hereditary coproporphyria (HCP) generated with TALEN and CRISPR-Cas9

2017-02-17

Abstract excerpt

<h4>ABSTRACT</h4> Defects in the enzymes involved in heme biosynthesis result in a group of human metabolic genetic disorders known as porphyrias. Using a zebrafish model for human hepatoerythropoietic porphyria (HEP), caused by defective uroporphyrinogen decarboxylase (Urod), the fifth enzyme in the heme biosynthesis pathway, we recently have found a novel aspect of porphyria pathogenesis. However, no hereditabl...

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Literature Corpus work: 59ae65e5-b552-5cdc-9d29-aacbd5bdb3a0
DOI: 10.1101/109553

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