Article
montalcino, A zebrafish model for variegate porphyria.
Experimental hematology - 1 Sept 2008
Dooley Kimberly A, Fraenkel Paula G, Langer Nathaniel B, Schmid Bettina, Davidson Alan J, Weber Gerhard, Chiang Ken, Foott Helen, Dwyer Caitlin, Wingert Rebecca A, Zhou Yi, Paw Barry H, Zon Leonard I
Abstract excerpt
OBJECTIVE: Inherited or acquired mutations in the heme biosynthetic pathway leads to a debilitating class of diseases collectively known as porphyrias, with symptoms that can include anemia, cutaneous photosensitivity, and neurovisceral dysfunction. In a genetic screen for hematopoietic mutants, we isolated a zebrafish mutant, montalcino (mno), which displays hypochromic anemia and porphyria. The objective of...
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