Article
Association of Forced Vital Capacity with the Developmental Gene NCOR2.
PloS one - 1 Jan 2016
Minelli Cosetta, Dean Charlotte H, Hind Matthew, Alves Alexessander Couto, Amaral André F S, Siroux Valerie, Huikari Ville, Soler Artigas María, Evans David M, Loth Daan W, Bossé Yohan, Postma Dirkje S, Sin Don, Thompson John, Demenais Florence, Henderson John, Bouzigon Emmanuelle, Jarvis Deborah, Järvelin Marjo-Riitta, Burney Peter
Abstract excerpt
BACKGROUND: Forced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence of chronic respiratory conditions. Epidemiological evidence highlights the role of early life factors on adult FVC, pointing to environmental exposures and genes affecting lung development as risk factors for low FVC later in life. Although highly heritable, a small number of genes have been found associated...
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