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Article

In Crystallo Capture of a Covalent Intermediate in the UDP-Galactopyranose Mutase Reaction.

Biochemistry - 16 Feb 2016

Mehra-Chaudhary Ritcha, Dai Yumin, Sobrado Pablo, Tanner John J

Abstract excerpt

UDP-galactopyranose mutase (UGM) plays an essential role in galactofuranose biosynthesis in pathogens by catalyzing the conversion of UDP-galactopyranose to UDP-galactofuranose. Here we report the first crystal structure of a covalent intermediate in the UGM reaction. The 2.3 Å resolution structure reveals UDP bound in the active site and galactopyranose linked to the FAD through a covalent bond between the...

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Identifiers

PMID: 26836146
DOI: 10.1021/acs.biochem.6b00035
PMCID: PMC4819441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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