Article
Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs.
Nature structural biology - 1 Feb 2001
Persson K, Ly H D, Dieckelmann M, Wakarchuk W W, Withers S G, Strynadka N C
Abstract excerpt
Many bacterial pathogens express lipooligosaccharides that mimic human cell surface glycoconjugates, enabling them to attach to host receptors and to evade the immune response. In Neisseria meningitidis, the galactosyltransferase LgtC catalyzes a key step in the biosynthesis of lipooligosaccharide structure by transferring alpha-d-galactose from UDP-galactose to a terminal lactose. The product retains the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.