Article
miR-23∼27∼24 clusters control effector T cell differentiation and function.
The Journal of experimental medicine - 8 Feb 2016
Cho Sunglim, Wu Cheng-Jang, Yasuda Tomoharu, Cruz Leilani O, Khan Aly Azeem, Lin Ling-Li, Nguyen Duc T, Miller Marina, Lee Hyang-Mi, Kuo Ming-Ling, Broide David H, Rajewsky Klaus, Rudensky Alexander Y, Lu Li-Fan
Abstract excerpt
Coordinated repression of gene expression by evolutionarily conserved microRNA (miRNA) clusters and paralogs ensures that miRNAs efficiently exert their biological impact. Combining both loss- and gain-of-function genetic approaches, we show that the miR-23∼27∼24 clusters regulate multiple aspects of T cell biology, particularly helper T (Th) 2 immunity. Low expression of this miRNA family confers proper effector...
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