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MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation

9 Nov 2017

Abstract excerpt

MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate regulation of multiple target genes in a wide variety of cells. Type 2 innate lymphoid cells (ILC2s) are tissue sentinel mediators of allergic inflammation. We established the physiological requirements for miRNAs in ILC2 homeostasis and immune function and compared the global miRNA repertoire of resting and activated ILC2s and T helper type...

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PMID: 29122948
DOI: 10.1084/jem.20170545

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