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A systems immunology approach identifies the collective impact of 5 miRs in Th2 inflammation

6 Jun 2018

Abstract excerpt

Allergic asthma is a chronic inflammatory disease dominated by a CD4+ T helper 2 (Th2) cell signature. The immune response amplifies in self-enforcing loops, promoting Th2-driven cellular immunity and leaving the host unable to terminate inflammation. Posttranscriptional mechanisms, including microRNAs (miRs), are pivotal in maintaining immune homeostasis. Since an altered expression of various miRs has been...

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PMID: 29875322
DOI: 10.1172/jci.insight.97503

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