STK11/LKB1-Deficient Phenotype Rather Than Mutation Diminishes Immunotherapy Efficacy and Represents STING/Type I Interferon/CD8+ T-Cell Dysfunction in NSCLC.

doi:10.1016/j.jtho.2023.07.020

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Article

STK11/LKB1-Deficient Phenotype Rather Than Mutation Diminishes Immunotherapy Efficacy and Represents STING/Type I Interferon/CD8+ T-Cell Dysfunction in NSCLC.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Dec 2023

Li Anlin, Wang Yuanyuan, Yu Zhixin, Tan Zihui, He Lina, Fu Sha, Shi Mengting, Du Wei, Luo Linfeng, Li Zhichao, Liu Jiaqing, Zhou Yixin, Fang Wenfeng, Yang Yunpeng, Zhang Li, Hong Shaodong

Abstract excerpt

INTRODUCTION: Conflicting findings have been reported regarding the association between STK11/LKB1 mutations and immune checkpoint inhibitor (ICB) efficacy in NSCLC. It has been reported that tumors could exhibit impaired STK11/LKB1 function even without STK11 mutations. We hypothesized that STK11 phenotype rather than mutation may better stratify ICB outcomes. METHODS: Selected functional STK11 events and LKB1...

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PMID: 37495171
DOI: 10.1016/j.jtho.2023.07.020

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