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Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

1 Feb 2016

Abstract excerpt

Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 26833098
DOI: 10.1038/ncomms10494

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