Article
Common variants in the 5' region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study.
American journal of human genetics - 1 Aug 2004
Jiang Y, Wilk J B, Borecki I, Williamson S, DeStefano A L, Xu G, Liu J, Ellison R C, Province M, Myers R H
Abstract excerpt
Linkage of body mass index (BMI) to a broad region of chromosome 7q22-35 has been reported in multiple studies. We previously published a multipoint LOD score of 4.9 at D7S1804 for BMI from the National Heart, Lung, and Blood Institute Family Heart Study. Leptin (LEP), the human homolog of the mouse obesity (ob) gene, is positioned near the linkage peak and is the most prominent candidate gene in this region....
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