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Article

Replication and explorations of high-order epistasis using a large advanced intercross line pedigree.

PLoS genetics - 1 Jul 2011

Pettersson Mats, Besnier Francois, Siegel Paul B, Carlborg Orjan

Abstract excerpt

Dissection of the genetic architecture of complex traits persists as a major challenge in biology; despite considerable efforts, much remains unclear including the role and importance of genetic interactions. This study provides empirical evidence for a strong and persistent contribution of both second- and third-order epistatic interactions to long-term selection response for body weight in two divergently...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21814519
DOI: 10.1371/journal.pgen.1002180
PMCID: PMC3140984

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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