Article
Genomic dissection of Australian Bordetella pertussis isolates from the 2008-2012 epidemic.
The Journal of infection - 1 Apr 2016
Safarchi Azadeh, Octavia Sophie, Wu Sunny Z, Kaur Sandeep, Sintchenko Vitali, Gilbert Gwendolyn L, Wood Nicholas, McIntyre Peter, Marshall Helen, Keil Anthony D, Lan Ruiting
Abstract excerpt
OBJECTIVES: Despite high pertussis vaccination coverage, Australia experienced a prolonged epidemic in 2008-2012. The predominant Bordetella pertussis genotype harboured pertussis toxin promoter allele, ptxP3, and pertactin gene allele, prn2. The emergence and expansion of prn non-expressing isolates (Prn negative), were also observed. We aimed to investigate the microevolution and genomic diversity of epidemic...
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