Article
HSPA6 is an ulcerative colitis susceptibility factor that is induced by cigarette smoke and protects intestinal epithelial cells by stabilizing anti-apoptotic Bcl-XL.
Biochimica et biophysica acta - 1 Apr 2016
Regeling Anouk, Imhann Floris, Volders Haukeline H, Blokzijl Tjasso, Bloks Vincent W, Weersma Rinse K, Dijkstra Gerard, Faber Klaas Nico
Abstract excerpt
BACKGROUND: Cigarette smoking ameliorates ulcerative colitis (UC) and aggravates Crohn's disease (CD). Cigarette smoke suppresses inflammation-induced apoptosis in intestinal epithelial cells (DLD-1), which may explain its protective effect in UC. Here, we performed transcriptome profiling of cigarette smoke extract (CSE)-exposed DLD-1 and Jurkat cells (T-lymphocytes) and related this to UC susceptibility genes...
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