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Article

Acute promyelocytic leukemia with cryptic t(15;17) on isochromosome 17: a case report and review of literature.

International journal of clinical and experimental pathology - 1 Jan 2015

Tang Yuting, Wang Ying, Hu Liang, Meng Fankai, Xu Danmei, Wan Kai, Huang Lifang, Li Chunrui, Zhou Jianfeng

Abstract excerpt

Acute Promyelocytic Leukemia (APL) is one of the most curable leukemia which shows great sensitivity to all-trans retinoic acid (ATRA) although a small number of the patients present poor prognosis and short survival. Isochromosome 17 in APL which usually bears an additional copy of RARA/PML fusion gene is considered to be a negative factor on its prognosis. Cryptic t(15;17) on i(17q) leads to an extra copy of...

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Identifiers

PMID: 26823883
PMCID: PMC4713669

Genes

PML
RARA

Provenance

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