Article
A new chromosome translocation t(7;16)(q31,q22) change during an acute promyelocytic leukemia relapse.
Cytogenetic and genome research - 1 Jan 2013
Cao Y, Yuan R, Wang Y, Chen R, Huang M, Zhou J
Abstract excerpt
The translocation t(15;17), which results in the PML-RARα fusion gene, is a characteristic chromosomal translocation in acute promyelocytic leukemia (APL). But additional chromosome aberrations in APL are increasingly recognized. Here, we report on a 16-year-old APL patient who had an fms-related tyrosine kinase 3-internal tandem duplication (FLT3-ITD) and a 46,XY,t(15;17)(q22;q21)-16+mar karyotype at diagnosis....
Topics
- Abnormal Karyotype
- Adolescent
- Brain
- Chromosomes, Human, Pair 15
- Chromosomes, Human, Pair 16
- Chromosomes, Human, Pair 17
- Chromosomes, Human, Pair 7
- Humans
- Leukemia, Promyelocytic, Acute
- Male
- Mutation