Article
Novel variants in ZNF34 and other brain-expressed transcription factors are shared among early-onset MDD relatives.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2016
Subaran Ryan L, Odgerel Zagaa, Swaminathan Rajeswari, Glatt Charles E, Weissman Myrna M
Abstract excerpt
There are no known genetic variants with large effects on susceptibility to major depressive disorder (MDD). Although one proposed study approach is to increase sensitivity by increasing sample sizes, another is to focus on families with multiple affected individuals to identify genes with rare or novel variants with strong effects. Choosing the family-based approach, we performed whole-exome analysis on affected...
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