Article
Promoter polymorphism at the tumour necrosis factor/lymphotoxin-alpha locus is associated with type of diabetes but not with susceptibility to sight-threatening diabetic retinopathy.
Diabetes & vascular disease research - 1 Mar 2016
Kaidonis Georgia, Craig Jamie E, Gillies Mark C, Abhary Sotoodeh, Essex Rohan W, Chang John H, Pal Bishwanath, Pefkianaki Maria, Daniell Mark, Lake Stewart, Petrovsky Nikolai, Burdon Kathryn P
Abstract excerpt
AIM: To investigate, in a large cohort of 2494 individuals with diabetes mellitus, whether functional single nucleotide polymorphisms in the promoter region of tumour necrosis factor (TNF) and lymphotoxin-alpha (LTA) genes are associated with type of diabetes or presence of diabetic retinopathy. METHODS: A total of 334 type 1 diabetes and 999 type 2 diabetes participants with sight-threatening diabetic...
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