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Article

The severity of FIP1L1-PDGFRA-positive chronic eosinophilic leukaemia is associated with polymorphic variation at the IL5RA locus.

Leukemia - 1 Dec 2007

Burgstaller S, Kreil S, Waghorn K, Metzgeroth G, Preudhomme C, Zoi K, White H, Cilloni D, Zoi C, Brito-Babapulle F, Walz C, Reiter A, Cross N C P

Abstract excerpt

We have investigated the hypothesis that constitutional genetic variation in IL-5 signalling may be associated with the development or severity of FIP1L1-PDGFRA-positive chronic eosinophilic leukaemia (CEL) in humans. We genotyped six single-nucleotide polymorphisms (SNP) within or close to the IL5RA or IL5 genes in 82 patients with FIP1L1-PDGFRA-positive CEL plus, as controls, healthy individuals (n=100),...

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Share to Eosinophils
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypereosinophilic Syndrome

Share to Interleukin-5

Share to Leukocyte Count

Share to mRNA Cleavage and Polyadenylation Factors

Share to Oncogene Proteins, Fusion

Share to Receptor, Platelet-Derived Growth Factor alpha

Source

Identifiers

PMID: 17914408
DOI: 10.1038/sj.leu.2404977

Genes

PDGFRA
CEL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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