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Probing the nuclear import signal and nuclear transport molecular determinants of PRV ICP22

25 Jan 2016

Abstract excerpt

BACKGROUND: Herpes simplex virus 1 (HSV-1) ICP22 is a multifunctional protein and important for HSV-1 replication. Pseudorabies virus (PRV) ICP22 (P-ICP22) is a homologue of HSV-1 ICP22 and is reported to be able to selectively modify the transcription of different kinetic classes of PRV genes, however, the subcellular localization, localization signal and molecular determinants for its transport to execute this...

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PMID: 26816613
DOI: 10.1186/s13578-016-0069-7

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