A truncation mutation of the neurovirulence ICP22 protein produced by a recombinant HSV-1 generated by bacterial artificial chromosome technology targets infected cell nuclei.

Abstract excerpt

The major regulatory protein ICP22 is unique among the immediate early proteins of herpes simplex virus. Viruses deleted for ICP22 replicate well in actively dividing cells, but not in quiescent cells or certain rodent lines. Accordingly, ICP22 represents an understudied herpes simplex virus (HSV...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chromosomes, Artificial, Bacterial
• Share to Gene Expression Regulation, Viral
• Share to Herpes Simplex